Figure 2.

Type of mutations, frequency, and affected PIK3CA domains across breast cancers from The Cancer Genome Atlas (TCGA) Network and selected solid tumors from the Catalog Of Somatic Mutations In Cancer (COSMIC) datasets, including the mutations and exons covered by the FDA-approved the RT-PCR test. The tumor types included in this analysis are non-small cell lung cancer (i.e., squamous cell and adenocarcinoma), esophageal cancer, stomach cancer, colorectal cancer, cholangiocarcinoma, pancreatic cancer, liver cancer, bladder cancer, prostate adenocarcinoma, uterine cancer (i.e., endometrioid, serous, and carcinosarcoma), ovarian cancer, and invasive breast cancer. The types of mutations and their likely pathogenicity are color-coded based on the legend at the bottom.