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. 2021 Mar 25;12:569287. doi: 10.3389/fimmu.2021.569287

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Copyright © 2021 Didona, Scarsella, Fehresti, Solimani, Juratli, Göbel, Mühlenbein, Holiangu, Pieper, Korff, Schmidt, Sitaru, Eming, Hertl and Pollmann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of treatment with topical glucocorticoids (clobetasol propionate ointment) on peripheral blood T cell responses against bullous pemphigoid (BP) 180 in BP patients. Shown are T cells producing IFN-γ, IL-5 or IL-17 upon ex vivo stimulation with the immunodominant NH2-terminal NC16a domain of BP180 (BP180-NH2) or the COOH terminus of BP180 (BP180-COOH), respectively. BP patients with active disease were either untreated or had been treated topically with 0.05% clobetasol propionate ointment for at least 5 days. Differences between the groups were analyzed using Mann-Whitney U-test for non-parametric data (*p < 0.05, **p < 0.01).