Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 30;15(2):473–488. doi: 10.1038/s41396-020-00789-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — Three different models of direct contact with commensal streptococci (blue cells) leading to S. mutans (direct contact white cells with green outline, noncontact green cells) peptide signaling inhibition and conserved gene expression patterns. a A commensal-derived inhibitory product from the initiation of contact with S. mutans is secreted to modify S. mutans behavior and peptide sensing across the entire S. mutans population. b A subset of S. mutans that is in direct contact with commensals produces an inhibitory signal that modifies behavior for the rest of the population, including those noncontacted S. mutans cells. c Transient contact between an oral commensal (blue) and S. mutans cell (green/green outline), prior to ComRS signaling activation, leads to posttranscriptional modifications in ComRS signaling. In the proposed mechanism shown, contact between S. mutans and commensal leads to sequestering of ComR with an unknown interaction partner, preventing ComR-XIP complex binding to the PcomX promoter and genetic competence activation.