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. 2020 Jun 17;42(2):242–251. doi: 10.1038/s41401-020-0450-2

Fig. 1. The expression and activity of Sirt1 decreased in high glucose-induced renal tubular epithelial cell EMT in vivo and in vitro.

Fig. 1

a The relative protein levels of EMT-associated proteins in mice. Data are expressed as the mean ± SD, n = 6. #P < 0.05, ##P < 0.01 vs. db/m. b PAS, H&E, Sirius red, and Masson staining of renal cortex sections of mice. Scale bar = 20 μm. c The relative protein levels of Sirt1 in mice. Data are expressed as the mean ± SD, n = 6. ##P < 0.01 vs. db/m. d The expression of Sirt1 in mice, as shown by immunohistochemistry. Scale bar = 20 μm. e The relative protein levels of EMT-associated proteins in HK-2 cells. Data are expressed as the mean ± SD, n = 3. #P < 0.05, ##P < 0.01 vs. NG. f The relative protein levels of Sirt1 in HK-2 cells. Data are expressed as the mean ± SD, n = 3. #P < 0.05 vs. NG. g The expression of Sirt1 in HK-2 cells, as shown by immunohistochemistry. Scale bar = 20 μm.