Table 1.

Pharmacokinetic parameters for different doses of LSD based on compartmental modeling.

	Dose (µg)		K01 (1/h)	λz (1/h)	Vz/F (L)	Cmax (ng/mL)	tmax (h)	t1/2 (h)	AUC∞ (ng h/mL)	CL/F (L/h)
LSD	25	Geometric mean (95% CI)	2.0 (1.3–3.2)	0.19 (0.16–0.24)	38 (30–47)	0.49 (0.41–0.58)	1.2 (0.9–1.7)	3.6 (2.9–4.4)	3.5 (2.7–4.5)	7.2 (5.6–9.3)
		Range	0.40–15.1	0.06–0.35	15–102	0.20–0.71	0.29–2.7	2.0–12	1.1–12	2.0–22
	50	Geometric mean (95% CI)	2.1 (1.5–3.0)	0.19 (0.16–0.23)	35 (31–38)	1.1 (0.99–1.2)	1.2 (0.95–1.6)	3.6 (3.0–4.2)	7.4 (6.2–8.9)	6.7 (5.6–8.0)
		Range	0.43–19.8	0.06–0.44	22–46	0.68–1.6	0.25–2.5	1.6–11	4.2–25	2.0–11.8
	100	Geometric mean (95% CI)	1.8 (1.4–2.4)	0.18 (0.15–0.21)	37 (33–42)	2.0 (1.9–2.2)	1.4 (1.2–1.7)	3.9 (3.2–4.7)	15 (12–18)	6.6 (5.4–8.0)
		Range	0.7–4.5	0.06–0.24	22–51	1.7–2.9	0.74–2.5	2.9–12	11–47	2.1–9.4
	200	Geometric mean (95% CI)	1.6 (1.2–2.1)	0.17 (0.14–0.20)	39 (35–43)	3.9 (3.5–4.3)	1.5 (1.3–1.9)	4.1 (3.4–4.9)	31 (25–38)	6.5 (5.3–8.0)
		Range	0.45–5.03	0.06–0.35	25–67	2.5–6.0	0.70–5.0	2.0–11	18–127	1.6–11
	200 + Ketanserin	Geometric mean (95% CI)	2.3 (1.4–3.8)	0.15 (0.13–0.18)	36 (32–40)	4.4 (4.0–4.8)	1.2 (0.85–1.8)	4.5 (3.8–5.3)	36 (30–43)	5.6 (4.6–6.8)
		Range	0.6–20.0	0.06–0.24	23–47	3.1–6.8	0.25–4.1	0.25–4.1	25–110	1.8–7.9

AUC_∞ area under the plasma concentration–time curve from time zero to infinity, CL/F apparent total clearance, C_max estimated maximum plasma concentration, t_1/2 estimated plasma elimination half-life, t_max estimated time to reach C_max, k₀₁ first-order absorption koefficient, λ_z first-order elimination coefficient, V_z/F volume of distribution.