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. 2020 Oct 15;46(3):537–544. doi: 10.1038/s41386-020-00883-6

Table 1.

Pharmacokinetic parameters for different doses of LSD based on compartmental modeling.

Dose (µg) K01 (1/h) λz (1/h) Vz/F (L) Cmax (ng/mL) tmax (h) t1/2 (h) AUC
(ng h/mL)
CL/F (L/h)
LSD 25 Geometric mean (95% CI) 2.0 (1.3–3.2) 0.19 (0.16–0.24) 38 (30–47) 0.49 (0.41–0.58) 1.2 (0.9–1.7) 3.6 (2.9–4.4) 3.5 (2.7–4.5) 7.2 (5.6–9.3)
Range 0.40–15.1 0.06–0.35 15–102 0.20–0.71 0.29–2.7 2.0–12 1.1–12 2.0–22
50 Geometric mean (95% CI) 2.1 (1.5–3.0) 0.19 (0.16–0.23) 35 (31–38) 1.1 (0.99–1.2) 1.2 (0.95–1.6) 3.6 (3.0–4.2) 7.4 (6.2–8.9) 6.7 (5.6–8.0)
Range 0.43–19.8 0.06–0.44 22–46 0.68–1.6 0.25–2.5 1.6–11 4.2–25 2.0–11.8
100 Geometric mean (95% CI) 1.8 (1.4–2.4) 0.18 (0.15–0.21) 37 (33–42) 2.0 (1.9–2.2) 1.4 (1.2–1.7) 3.9 (3.2–4.7) 15 (12–18) 6.6 (5.4–8.0)
Range 0.7–4.5 0.06–0.24 22–51 1.7–2.9 0.74–2.5 2.9–12 11–47 2.1–9.4
200 Geometric mean (95% CI) 1.6 (1.2–2.1) 0.17 (0.14–0.20) 39 (35–43) 3.9 (3.5–4.3) 1.5 (1.3–1.9) 4.1 (3.4–4.9) 31 (25–38) 6.5 (5.3–8.0)
Range 0.45–5.03 0.06–0.35 25–67 2.5–6.0 0.70–5.0 2.0–11 18–127 1.6–11
200 + Ketanserin Geometric mean (95% CI) 2.3 (1.4–3.8) 0.15 (0.13–0.18) 36 (32–40) 4.4 (4.0–4.8) 1.2 (0.85–1.8) 4.5 (3.8–5.3) 36 (30–43) 5.6 (4.6–6.8)
Range 0.6–20.0 0.06–0.24 23–47 3.1–6.8 0.25–4.1 0.25–4.1 25–110 1.8–7.9

AUC area under the plasma concentration–time curve from time zero to infinity, CL/F apparent total clearance, Cmax estimated maximum plasma concentration, t1/2 estimated plasma elimination half-life, tmax estimated time to reach Cmax, k01 first-order absorption koefficient, λz first-order elimination coefficient, Vz/F volume of distribution.