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. 2021 Apr 7;12:2086. doi: 10.1038/s41467-021-22427-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The interaction between the receptor and the αH5, viewing from the TM6, TM7-H8 front angle. The receptor is colored in cyan and Gα_q is colored in orange. b The interaction between the receptor and Gα_q, viewing from the TM5, TM3, and ICL2 front angle. c the ICL2/Gβ interaction. The receptor is colored in cyan and Gβ is colored in slate. Density map of designated region is set to contour level of 3.0. d An overall comparison of the H₁R/G_q complex with the M1R/G₁₁ complex (PDB 6OIJ). e A comparison of the engagement of αH5 to receptor between the H₁R/G_q complex with the M1R/G₁₁ complex. f A comparison of the αN displacements of G_q/11 in receptor engagement. M1R/G₁₁ (PDB 6OIJ), HT2AR/mini-G_q (PDB 6WHA) and GDP-bound G_q (PDB 3AH8).