a Representative AP waveforms showed shortened APDs and TA by ACO administration. Representative AP waveforms showed shortened APDs (b–d) and TA (b), EAD (c) and DAD (d) by MACO administration. Quantitative group data for AP parameters: e Concentration-dependent effects of ACO on APD30, APD50, and APD90; f Concentration-dependent effects of ACO on APA and RMP; g Concentration-dependent effects of MACO on APD30, APD50, and APD90; h Concentration-dependent effects of MACO on APA and RMP. There were seven cells from three guinea pig hearts in each group. *P < 0.05, **P < 0.01 vs. control group.