Table 1.
The onset time and incidence of various arrhythmias and mortality induced by ACO and MACO in guinea pigs.
| Type of arrhythmia | ACO group (n = 10) | MACO group (n = 10) | ||
|---|---|---|---|---|
| Onset time (min) | Incidence | Onset time (min) | Incidence | |
| VPB | 22.79 ± 7.90 | 8/10 | 1.46 ± 0.66** | 9/10 |
| AVB | 22.75 ± 13.70 | 5/10 | 1.46 ± 0.66** | 8/10 |
| VT | 42.30 ± 15.69 | 5/10 | 2.53 ± 0.87** | 9/10 |
| VF | 39.65 ± 7.17 | 3/10 | 3.50 ± 1.19** | 9/10* |
| Mortality | 56.32 ± 11.40 | 4/10 | 23.01 ± 14.92** | 10/10** |
Incidence is the ratio of animals occurring arrhythmic events or death to the whole animals. The onset time of VPB, AVB, VT, VF, and the death time of the animals in MACO group occurred much earlier than those in ACO group (P < 0.01, respectively). However, the incidences of VPB, AVB, and VT had no obvious difference in these two groups, while the incidence of VF and mortality in MACO group were significantly higher than those in ACO group (P < 0.05 or P < 0.01, respectively).
n number of animals, VPB ventricular premature beats, AVB atrioventricular blockade, VT ventricular tachycardia, VF ventricular fibrillation.
*P < 0.05 or **P < 0.01, respectively vs. ACO group.