Table 4.
Parameters | Pre-MACO (n) | Post-30 μM MACO (n) |
---|---|---|
V1/2 of activation (mV) | −39.48 ± 0.74 (15) | −74.54 ± 0.72** (15) |
k of activation (mV) | 4.21 ± 0.36 (15) | 3.57 ± 0.24 (15) |
V1/2 of inactivation (mV) | −79.34 ± 0.97 (15) | −81.34 ± 1.06 (15) |
k of inactivation (mV) | 4.45 ± 0.14 (15) | 4.97 ± 0.31 (15) |
τ fast recovery (ms) | 11.26 ± 1.32 (7) | 6.32 ± 0.44** (11) |
τ fast amplitude (%) | 86.82 ± 2.13 (7) | 83.43 ± 1.42 (11) |
τ slow recovery (ms) | 55.45 ± 8.26 (7) | 152.72 ± 9.03** (11) |
τ slow amplitude (%) | 13.18 ± 1.32 (7) | 16.57 ± 1.42 (11) |
MACO accelerated the activation and fast recovery of peak INa, and reduced the slow recovery of peak INa significantly (**P < 0.01 vs. pre-MACO group).
V1/2 half activation/inactivation voltage, k slope factor, τ recovery time consistent, n number of cells.