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. 2020 Aug 3;42(2):218–229. doi: 10.1038/s41401-020-0467-6

Table 4.

Effects of MACO on the kinetics of INa.

Parameters Pre-MACO (n) Post-30 μM MACO (n)
V1/2 of activation (mV) −39.48 ± 0.74 (15) −74.54 ± 0.72** (15)
k of activation (mV) 4.21 ± 0.36 (15) 3.57 ± 0.24 (15)
V1/2 of inactivation (mV) −79.34 ± 0.97 (15) −81.34 ± 1.06 (15)
k of inactivation (mV) 4.45 ± 0.14 (15) 4.97 ± 0.31 (15)
τ fast recovery (ms) 11.26 ± 1.32 (7) 6.32 ± 0.44** (11)
τ fast amplitude (%) 86.82 ± 2.13 (7) 83.43 ± 1.42 (11)
τ slow recovery (ms) 55.45 ± 8.26 (7) 152.72 ± 9.03** (11)
τ slow amplitude (%) 13.18 ± 1.32 (7) 16.57 ± 1.42 (11)

MACO accelerated the activation and fast recovery of peak INa, and reduced the slow recovery of peak INa significantly (**P < 0.01 vs. pre-MACO group).

V1/2 half activation/inactivation voltage, k slope factor, τ recovery time consistent, n number of cells.