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Variance polygenic score (vPGS) validation in the UK Biobank.
| Model 1 | Model 2 | |
|---|---|---|
| vPGS | Beta (SE) | Beta (SE) |
| 95% CI | 95% CI | |
| p value | p value | |
| 0.019 (0.005) | 0.019 (0.005) | |
| [0.009, 0.029] | [0.009, 0.029] | |
| 1.01E−04 | 1.44E−04 |
Abbreviations: SE, standard error; CI, confidence interval. Results show the association between the vPGS and the between-individual variance in BMI in a 20% holdout sample of the UK Biobank. Model 2 adjusts for the effect of the mean PGS (mPGS). Unique N = 81,375.
