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. 2020 Oct 3;15(2):534–544. doi: 10.1038/s41396-020-00794-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Each point represents the proportion of bacterial phenotypes (n = 24 clones per population) that exist in each population. Shaded lines represent individual populations. Dashed lines represent model fit from a GLM that includes a polynomial spline (knots = 2). b Lines represent the phage titres present in each population throughout the evolution experiment. c Genetic diversity (Shannon’s diversity index) of the CRISPR2 array during the first 12 days of the experiment from amplicon sequence data.