Fig. 4. Intracellular Kv1.3 channels regulate proliferation and respiration.

A Proliferation assay of HEK293/Kv1.3 cells treated with PAPTP (100 nM; n = 5). B Residual O₂ consumption (ROX) corrected Routine, Leak and maximal ETS respiration in HEK293/Kv1.3 cells treated with PAPTP (100 nM; n = 5). C ATP turnover in HEK293/Kv1.3 cells treated with PAPTP (100 nM; n = 5). D Spare respiratory capacity in HEK293/Kv1.3 cells treated with PAPTP (100 nM; n = 5). Data were mean ± SEM. Data were analysed using a paired Student’s t-test. *p < 0.05 and ***p < 0.001.