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. 2020 Nov 3;28(4):1270–1283. doi: 10.1038/s41418-020-00650-6

Fig. 8. The impact of IL-24 on IL-4-stimulated STAT6/PPAR-γ signaling and SOCS1/3 expression in macrophages.

Fig. 8

a IL-24 promoted IL-4-induced STAT6/PPAR-γ signaling. Upper panel: representative Western blot results for STAT6, p-STAT6, and PPAR-γ at different time points stimulated with IL-4 and IL-24/IL-4. Lower panel: figures showing the data with five mice analyzed. Statistical analysis was performed using one-way ANOVA (**p < 0.01; ***p < 0.001). b IL-24 indirectly repressed SOCS1/3 expression. Upper panel: representative Western blot results for SOCS1 and SOCS3 at the indicated time points following IL-4 and IL-24/IL-4 stimulation. Lower panel: figures showing the data with five mice studied. Statistical analysis was performed using one-way ANOVA (**p < 0.01; ***p < 0.001). c IL-24 did not affect MAPK (p38, ERK1/2, and JNK), Akt and PI3K signaling. PPAR-γ peroxisome proliferator-activated receptor gamma, p-STAT6 phosphorylated STAT6, SOCS1 and SOCS3 suppressor of cytokine signaling 1 and suppressor of cytokine signaling 3, STAT6 signal transducer and activator of transcription 6.