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. 2020 May 4;35(2):548–558. doi: 10.1038/s41433-020-0896-y

Fig. 5. Subretinal hemorrhage in the macula of a neovascular AMD eye.

Fig. 5

The scale bar in (c) applies to both (b) and (c). a. Ex vivo color fundus photograph shows macular atrophy and annular subretinal hemorrhage (yellow circle). Green line, scan level of the ex vivo optical coherence tomography (OCT). b Subretinal hemorrhage is hyperreflective (yellow frame) on ex vivo OCT. Hyperreflective type 1 macular neovascularization (MNV) is seen; the extent is indicated by pink arrows. c Yellow frame indicates area of subretinal hemorrhage. Pink arrows, extent of the fibrovascular scar (Fv); black arrowheads, Bruch membrane. The Fv correlates to the type 1 MNV in (B). At this location, the retina is artifactually detached from the RPE, and the choroid, from the sclera. d Green frame, area detailed in panel e Orange arrowhead, subretinal hematoma mixed with fibrosis. At this location RPE is dysmorphic and continuous over a thin continuous BLamD, which overlies a fibrocellular scar with scattered blood cells. The overlying retina has dyslaminate HFL/ONL, and shortened inner segments, and absent outer segments. e Blood in the subretinal space is mixed with shed inner segments (yellow arrow), which harbor fragmented mitochondria [9]. Few inner segments extend beyond the external limiting membrane (green arrowhead). The HFL/ONL is dyslaminate. INL inner nuclear layer, OPL outer plexiform layer, HFL Henle fiber layer, ONL outer nuclear layer, RPE retinal pigment epithelium, BLamD basal lamina deposit.