Table 1.
Potential E199L-interacting proteins which are related to cell autophagy.
| Gene name | Protein name | Fold change | LFQ intensity E199L-IP | LFQ intensity E199L-IgG | Functional description | References |
|---|---|---|---|---|---|---|
| ARL8B | ADP-ribosylation factor-like protein 8B | 3.428346353 | 44,963,000 | 0 | A critical regulator of cargo delivery to lysosomes | (Garg et al. 2011) |
| LAMP2 | lysosomal associated membrane protein 2 | 3.365582298 | 36,729,000 | 0 | An important role in autophagosome formation |
(Fukushima et al. 2020) (Nguyen et al. 2018) |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 | 58.15290957 | 351,840,000 | 0 | Downregulation of PYCR2 induces the autophagy | (Ou et al. 2016) |
| BAG5 | BAG family molecular chaperone regulator 5 | 32.82806482 | 101,330,000 | 0 | Bcl-2-associated BAG5 regulates autophagy | (De snoo et al. 2019) |
| FLII | Protein flightless 1 homolog | 3.152638472 | 16,234,000 | 0 | FLII interacts with p62 to block its recognition of LC3 | (He et al. 2018) |