Table I.
Biochemical and hematological parameters assessed in EDTA-anticoagulated whole-blood from MG-63 xenograft-bearing athymic nude mice under dDAVP treatment.
| Treatment group | ||
|---|---|---|
| Parameter | Control (saline, mean ± SD) | dDAVP (1 µg kg-1, mean ± SD) |
| Weight (g)a | 21.4±1.3 | 21.1±1.7 |
| Hematocrit (%) | 38.7±1.8 | 38.0±2.3 |
| RBC (106 ml-1) | 75.6±4.3 | 71.3±3.9 |
| WBC (103 ml-1) | 2.9±1.0 | 3.0±0.2 |
| Platelets (106 ml-1) | 10.9±0.8 | 9.5±0.5b |
| Cholesterol (mg dl-1) | 81.2±13.5 | 86.8±13.2 |
| Total protein (g dl-1) | 4.2±0.4 | 4.3±0.5 |
| Direct bilirrubin (mg dl-1) | 0.02±0.01 | 0.01±0.0 |
| Creatinine (mg ml-1) | 0.13±0.04 | 0.14±0.04 |
| AST/GOT (IU l-1) | 135.7±16.3 | 157.2±47.8 |
| ALT (IU l-1) | 40.2±11.5 | 38.8±9.3 |
| Plasmatic albumin (g dl-1) | 2.5±0.2 | 2.5±0.4 |
aAt day 31 of osteosarcoma progression protocol. EDTA, ethylenediaminetetraacetic acid; dDAVP, Desmopressin; RBC, red blood cells; WBC, white blood cells; AST/GOT, aspartate aminotransferase; ALT, alanine aminotransferase.
bP<0.01.