Figure 4.

The Backpropagating Action Potential (bAP) Test evaluates the models' ability to reproduce experimentally determined bAP attenuation. (a) The first and last AP from the AP train recorded at distances of 50 µm and 350 µm from the soma. (b) The amplitude of the first AP (top) and the amplitude of the last AP (bottom) from the AP train decreased with increasing distance from the soma. Experimental values with the double standard deviations for bAPs are obtained from measurements of Golding et al.²⁴. Based on the first bAP, CA1 pyramidal cells can be divided into two groups – weakly-propagating and strongly-propagating (top)²⁴. (c) Model errors in the backpropagation of APs expressed by the number of standard deviations at different distances from the soma. The red horizontal line represents $sd=2$ and determines the maximum error accepted.