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. 2020 Jul 21;42(2):189–198. doi: 10.1038/s41401-020-0433-3

Fig. 5. D2 receptors mediate the antinociceptive effects of L-dopa in unilateral 6-OHDA lesioned mice.

Fig. 5

L-dopa plus SKF83566 (a), L-dopa plus sulpiride (b), SKF38393 (c), and ropinirole (d) were intrathecally administered to the saline control or unilateral 6-OHDA-lesioned mice. Two consecutive drug applications were separated by at least 3 days. PWTs in both hindpaws were measured in separate experiments before and 0.5, 1 and 24 h after drug injection. Two-way ANOVA was used to analyze the data in (a–d). a n = 7 in the saline group, n = 9 in the 6-OHDA group; Group: F (3, 119) = 30.71, P < 0.0001; Time: F (3, 119) = 8.16, P < 0.0001; Interaction: F (9, 119) = 1.01, P = 0.43. b n = 6 in the saline group, n = 9 in the 6-OHDA group; Group: F (3, 105) = 51.92, P < 0.0001; Time: F (3, 105) = 0.31, P = 0.82; Interaction: F (9, 105) = 0.12, P = 0.99. c n = 6 in the saline group, n = 9 in the 6-OHDA group; Group: F (3, 105) = 62.05, P < 0.0001; Time: F (3, 105) = 2.71, P = 0.06; Interaction: F (9, 105) = 0.46, P = 0.89. d n = 6 in the saline group, n = 9 in the 6-OHDA group; Group: F (3, 105) = 33.95, P < 0.0001; Time: F (3, 105) = 4.39, P = 0.006; Interaction: F (9, 106) = 1.03, P = 0.42. *P < 0.05, **P < 0.01, compared with baseline. Asterisks in red or green represent comparisons to their own baseline.