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. 2020 Nov 16;46(3):509–518. doi: 10.1038/s41386-020-00904-4

Fig. 4. Effects of intra-BNST PACAP(6–38) administration on operant ethanol and water self-administration in control and ethanol-dependent rats 8–10 h after ethanol vapor offset.

Fig. 4

Effects of intra-BNST PACAP(6–38) administration on operant ethanol (A–B) and water (C–D) self-administration in control, nondependent (left) and in ethanol-dependent rats (right) 8–10 h after ethanol vapor offset. Intra-BNST PACAP(6–38) administration did not affect ethanol self-administration in control, nondependent rats, while it significantly reduced the vapor-induced increase in ethanol self-administration in ethanol-dependent rats (A: g/kg; B: lever presses). The drug treatment did not affect concurrent responding for water (C: ml/kg; D: lever presses). Control and ethanol-dependent rats are depicted in orange and green, respectively. Data represent Mean ± SEM (n = 9–12/group). *p < 0.05, ***p < 0.001 vs. Vehicle, #p < 0.05, ###p < 0.001 vs. Controls.