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. 2020 Sep 18;42(2):252–263. doi: 10.1038/s41401-020-00520-4

Fig. 7. TUG-891 ameliorated HG-induced fibrosis and inflammation by activating the GPR120/β-arrestin2/TAB1 pathway in MPC5 podocytes.

Fig. 7

Representative Western blot images (a) and quantitative analyses (b) of fibronectin, collagen IV, α-SMA, TGF-β1 and IL-6, and β-actin levels in MPC5 cells. Representative Western blot images (d) and quantitative analyses (c) of TAB1, phospho-TAK1, phospho-IKKβ, phospho-NF-κB/NF-κB, phospho-JNK/JNK, phospho-p38/p38, and β-actin levels in MPC5 cells. e Schematic diagram of the mechanism of the GPR120 agonist TUG-891 in DN. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the NG group; #P < 0.05; ##P < 0.01, ###P < 0.001 compared with the HG group. All Western blot analyses were performed in triplicate.