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CDK4/6 inhibitors in combination with endocrine therapy in advanced HR+ HER2− breast cancer in various clinical settings.
| Drug | Combination | Line | Menopausal status | Clinical settings |
|---|---|---|---|---|
| Palbociclib | Letrozole | 1st | Post | PALOMA-2 |
| Fulvestrant | 2nd | Pre and Post | PALOMA-3 | |
| Ribociclib | Letrozole | 1st | Pre | MONALEESA-7 |
| Letrozole | 1st | Post | MONALEESA-2 | |
| Fulvestrant | 1st and 2nd | Post | MONALEESA-3 | |
| Abemaciclib | Letrozole | 1st | Post | MONARCH 3 |
| Fulvestrant | 2nd | Pre and Post | MONARCH 2 | |
| – | 2+ | Pre | MONARCH 1 |
