Fig. 1.

Multimodal platform (not to scale) for LSI and multispectral SFDI of the rat brain. A craniectomy ($\sim 6\mathrm{mm}\times 4\mathrm{mm}$ area) is performed to provide direct access to the brain for optical imaging. For SFDI, LEDs of 655, 730, and 850 nm are sequentially sent into a spatial light modulator that acts as a projector to send spatially modulated patterns of light onto the brain.⁸ A scientific CMOS camera detects the backscattered light. For LSI, an 809-nm laser illuminates the brain with coherent light, and the remitted speckle pattern is captured at 60 fps with a CCD camera.