Fig. 7. Effect of CAR treatment (20  mg/kg, p.o.) on LPS challenge (4  mg/kg, i.p., for 6  h)-induced changes in proinflammatory proteins and Nrf2 nuclear translocation.

a Representative gel blots depicting the levels of proinflammatory markers, including IL-1β, IL-6, TNF-α, as well as cytosolic and nuclear Nrf2 (GAPDH was used as a loading control, with Lamin B used as loading control for the nucleus); b IL-1β; c IL-6; d TNF-α; e cytosolic Nrf2 levels; and f nuclear Nrf2 levels. Mean ± SEM, n = 5–7 mice per group, *P < 0.05 vs the control group; ^#P< 0.05 vs the LPS group.