Figure 7.

Model of proSP-C BRICHOS T187R interactions during the catalytic cycle of Aβ42 self-aggregation. Monomeric proSP-C BRICHOS (blue stars) does not bind to monomeric or early oligomeric Aβ42 (purple circles) but to converted oligomers that consist of eight or fewer Aβ42 molecules and have acquired secondary nucleation competent structures (orange squares). Throughout this reaction, monomeric proSP-C BRICHOS T187R inhibits secondary nucleation pathways (red cross), thereby reducing the number of newly formed toxic oligomers.