Table 2.
Baseline Clinical Characteristics of Pregnant Women With Multidrug/Rifampicin-Resistant Tuberculosis (n = 108)
| Clinical Characteristics | No. (%) |
|---|---|
| Age: years, mean; SD | 28.0; 6.13 |
| Hb, g/dl: mean; SD (n = 102) | 10.4; 1.59 |
| BMI, kg/m2: mean; SD (n = 106) | 24.0; 4.85 |
| TB characteristics | |
| Culture positive at treatment initiation | 73 (68%) |
| Previous TB or MDR/RR-TB | 38/82 (46%) |
| Site of TB: Pulmonary | 108 (100%) |
| Extensive disease pattern on chest radiograph | 45/97 (46%) |
| Resistance pattern | |
| RR-TB/Rif-mono/MDR-TB | 83 (77%) |
| Pre-XDR-TB/XDR-TB | 25 (23%) |
| HIV-characteristics | |
| HIV-positive | 88 (81%) |
| HIV-positive patients on ART before MDR/RR-TB treatment started (n = 88): | 74 (83%) |
| Baseline CD4 count, median cells/mm3 [IQR] (n = 88) | 353 [165–511] |
| Pregnancy characteristics | |
| Pregnant before MDR/RR-TB treatment started | 89 (82%) |
| Gestational age at treatment start: weeks, median [IQR] | 22 [14–28] |
| Foetal exposure to any second-line drugs: Days, median [IQR] | 118 [70–208] |
Abbreviations: ART, antiretroviral therapy; BMI, body mass index; Hb, hemoglobin; HIV, human immunodeficiency virus; IQR, interquartile range; MDR/RR-TB, multidrug/rifampicin-resistant TB; Pre-XDR-TB, pre-extensively drug-resistant TB; Rif-mono, rifampicin monoresistant; RR-TB, rifampicin-resistant TB; SD, standard deviation; TB, tuberculosis; XDR-TB, extensively drug-resistant TB.
aExtensive disease was classified as bilateral disease and/or cavities on chest radiograph.