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. 2021 Apr 7;22:248. doi: 10.1186/s12864-021-07547-9

Table 3.

The top Blastp hit of Dermanyssus gallinae proteins homologous with house dust mite allergen groups

Group Function BLASTp query Top hit Gene Description Score E value
1 Cysteine Protease Der f 1 BAC53948 DEGAL5284g00180 Ctss protein cathepsin S protein cathepsin S 132 1.00E-31
2 MD-2 ML-lipid recognition/NPC2

Der p 2 AAF86462.1

PSOVI17g08010

DEGAL3867g00080

DEGAL6668g00010

Der f 2 allergen/epididymal secretory protein

Der p 2-like allergen

65.5

42.7

5.00E-12

3.00E-05

3 Serine protease - trypsin-like Der p 3 AAA19973.1 DEGAL1643g00010 Brain-specific serine protease 4 stubble-like 159 8.00E-40
4 Alpha amylase Der f 4 ABG35122.1 DEGAL4003g00110 Alpha-amylase-related protein 62 4.00E-10
6 Serine protease - chymotrypsin-like Der f 6 AAF28423.1 DEGAL1643g00010 Brain-specific serine protease 4 stubble-like 107 4.00E-24
8 Glutathione-S-transferase Der p 8 AAB32224.1 DEGAL2189g00680 Gluthathione S-transferase-3 mu 215 7.00E-57
9 Serine protease - collagenase-trypsin-like Der p 9 AAP57077.1 DEGAL3923g00020 Venom protease, serine protease proclotting enzyme 110 6.00E-25
10 Tropomyosin Der p 10 CAA75141.1 DEGAL59g00010 Tropomyosin-1, Sar s 10 allergen 310 3.00E-85
11 Paramysosin Der p 11 AAO73464.1 DEGAL2491g00020 Long form paramyosin 1269 0
12 Chitin-binding/peritrophin-A (chitinase)

PSOVI17g04210

PSOVI14g10800

DEGAL3304g00010

DEGAL1194g00010

Endochitinase chitinase 5

Peritrophic membrane chitin binding protein

53.5

258

1.00E-07

4.00E-69

13 Lipocalin - Fatty Acid Binding Protein Der p 13 ADK92390.1 DEGAL2772g00010 Fatty acid-binding protein 99.8 2.00E-22
14 Vitellogenin-like Der p 14 AAM21322.1 DEGAL5202g00200 Vitellogenin-like 46.6 7.00E-05
15 Chitinase Der p 15 AAY84564.2 DEGAL557g00040 Chitinase 3C 335 2.00E-92
16 Gelsolin Der f 16 AAM64112.1 DEGAL6121g00060 Flightless-1 protein, gelsolin domain 119 2.00E-27
18 Chitin-binding (chitinase) Der p 18 AAY84563.1 DEGAL557g00040 Chitinase 3C 196 1.00E-50
20 Arginine kinase Der p 20 ACD50950.1 DEGAL2192g00450 Creatine-adp Arginine Kinase Ternary Complex 621 1.00E-178
22 Lipid binding Der f 22 ABG35122.1 DEGAL7041g00020 NPC2-like Protein 68.2 1.00E-12
23 Peritrophin - chitin binding protein Der p 23 ACB46292.1 DEGAL2104g00010 Acidic mammalian chitinase 43.5 1.00E-05
24 Ubiquinol-cytochrome c reductase binding protein (UQCRB)-like Der p 24 ALA65345.1 DEGAL4789g00040 Ubiquinol-cytochrome c reductase 14 kDa subunit 68.9 3.00E-13
25 Triosephosphate isomerase Der p 25 QAT18637.1 DEGAL376g00010 Triosephosphate isomerase 344 1.00E-95
26 Myosin alkali light chain Der p 26 QAT18638.1 DEGAL877g00070 Myosin light chain alkali 140 7.00E-35
27 Serpin Der p 27 AIO08851.1 DEGAL4955g00010 Serpin B6-like antithrombin-III precursor 157 6.00E-39
28 Heat shock protein Der p 28 QAT18639.1 DEGAL3456g00110 Heat shock constitutive protein 70 934 0
29 Cyclophilin Der p 29 QAT18640.1 DEGAL2838g00020 Peptidyl-prolyl cis-trans isomerase E isoform X2 325 1.00E-89
30 Ferritin Der p 30 QAT18641.1 DEGAL3420g00020 Ferritin GF1 soma 126 1.00E-30
31 Cofilin Der p 31 QAT18642.1 DEGAL1595g00470 Cofilin/actin-depolymerizing factor homolog 169 3.00E-43
32 Inorganic pyrophosphatase Der p 32 QAT18643.1 DEGAL4942g00030 Inorganic pyrophosphatase-like 347 3.00E-96
33 Alpha tubulin 1A Der p 33 QAT18644.1 DEGAL3563g00110 Alpha 1A-tubulin 578 1.00E-165
34 Rid-like protein enamine/imine deaminase Der f 34 BAV90601.1 DEGAL6811g00140 RidA family reactive intermediate/imine deaminase 84 1.00E-17
35 Group 2 allergen Der f 35 BAX34757.1 DEGAL1450g00040 Der f 2/Der p 2/Pso o 2-like mite allergen 63.2 3.00E-11
37 Chitin binding protein Der f 37 AVD73319.1 DEGAL2715g00020 Peritrophin A 50.4 5.00E-07
39 Troponin C Der f 39 QBF67841.1 DEGAL4488g00100 Troponin C-like protein Troponin C 256 2.00E-69