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. 2021 Apr 7;21:156. doi: 10.1186/s12876-021-01743-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Pathologic findings in patients 1, 2, 3 and 4. Pathology findings in patient 1 [a, hematoxylin and eosin (H&E) stain, × 400; b, immunohistochemical stain of CD31, × 200] showed the endothelial cells with mild to moderate heterotype, hyperchromatic nuclei, and CD31 positive. Pathology findings in patient 2 (c, H&E stain, × 100; d, immunohistochemical stain of CD31, × 200) show that mitotic were found to anastomose with each other to form vascular like structures, favoring angiosarcoma and CD34 positive. Pathology findings in patient 3 (e, H&E stain, × 200; f, immunohistochemical stain of FLi-1, × 200) show malignant spindle cell tumor, favoring angiosarcoma and FLi-1 positive. Pathology findings in patient 4 (g, H&E stain, × 200; h, immunohistochemical stain of CD31, × 200) show malignant spindle cell tumor, favoring angiosarcoma and CD31 positive