Table 2.

Intragroup monthly basis analysis of Migraine attack, Headache severity, Headache duration and Painkiller number (A: Sodium Valproate; B: Sodium Valproate +Magnesium; C: Magnesium); *P values≤0.05 were considered statistically significant

Group	A	B	C	A vs B		A vs C				B vs C
				p- value	Mean Difference	95% CI	p- value	Mean Difference	95% CI	p- value	Mean Difference	95% CI
Migraine attack (n), mean ± SD
baseline	6.65 ± 1.65	6.89 ± 1.52	7.06 ± 1.54	0.621	− 0.24	− 0.85 to 0.37	0.248	− 0.41	−1.02 to 0.20	0.797	− 0.17	− 0.80 to 0.46
After 1 month	4.09 ± 0.99	4.04 ± 0.93	5.49 ± 1.45	0.972	0.05	− 0.40 to 0.48	<  0.001	− 1.40	− 1.84 to − 0.96	< 0.001	−1.45	− 1.90 to 0.99
After 2 month	2.83 ± 0.73	2.47 ± 0.71	4.21 ± 0.08	0.029	0.36	0.03 to 0.69	<  0.001	− 1.38	− 1.71 to − 1.06	<  0.001	− 1.74	−2.08 to − 1.40
After 3 month	1.60 ± 0.76	1.40 ± 0.75	3.91 ± 0.86	0.525	0.20	− 0.17 to 0.45	< 0.001	−2.31	− 2.62 to − 2.01	<  0.001	−2.51	− 2.77 to − 2.14
Headache severity, mean ± SD
baseline	5.33 ± 0.67	5.27 ± 0.79	5.16 ± 1.02	0.885	0.06	− 0.25 to 0.38	0.424	0.17	− 0.15 to 0.49	0.732	0.11	− 0.22 to 0.43
After 1 month	3.68 ± 0.81	3.69 ± 0.73	3.93 ± 1.24	0.999	− 0.01	−0.37 to 0.35	0.243	−0.25	− 0.61 to 0.11	0.287	− 0.24	−0.62 to 0.13
After 2 month	2.51 ± 0.68	2.16 ± 0.67	3.32 ± 0.78	0.01	0.35	− 0.06 to 0.61	<  0.001	− 0.81	− 1.08 to − 0.54	<  0.001	− 1.16	− 1.44 to 0.87
After 3 month	1.71 ± 0.55	1.26 ± 0.59	2.41 ± 1.15	0.002	0.45	− 0.13 to 0.75	< 0.001	−0.70	− 1.00 to − 0.39	<  0.001	− 1.15	− 1.46 to − 0.82
Headache duration (h), mean ± SD
baseline	11.56 ± 3.53	11.96 ± 1.73	10.99 ± 2.49	0.649	− 0.40	− 1.45 to 0.66	0.403	0.57	− 0.48 to 1.63	0.093	0.97	−0.12 to 2.07
After 1 month	10.39 ± 2.87	9.95 ± 1.80	10.64 ± 1.96	0.481	0.44	− 0.45 to 1.31	0.779	− 0.25	− 1.13 to 0.63	0.185	− 0.69	− 1.60 to 0.23
After 2 month	8.19 ± 2.76	7.22 ± 1.66	9.30 ± 1.84	0.019	0.97	0.12 to 1.80	0.006	−1.11	− 1.94 to − 0.26	<  0.001	− 2.08	− 2.94 to − 1.20
After 3 month	7.06 ± 2.53	6.08 ± 1.75	8.15 ± 1.83	0.013	0.98	0.17 to 1.77	0.004	− 1.09	− 1.90 to − 0.29	<  0.001	−2.07	− 2.90 to − 1.23
Painkiller (n),mean ± SD
baseline	6.45 ± 0.95	6.27 ± 0.94	6.05 ± 1.48	0.601	0.18	−0.26 to 0.62	0.083	0.40	−0.04 to 0.84	0.489	0.22	−0.24 to 0.68
After 1 month	4.15 ± 0.93	4.07 ± 0.73	4.55 ± 1.13	0.871	0.08	− 0.29 to 0.44	0.031	− 0.40	− 0.76 to − 0.03	0.010	−0.48	− 0.85 to − 0.09
After 2 month	3.11 ± 0.68	2.21 ± 0.75	3.46 ± 0.89	<  0.001	0.90	0.60 to 1.19	0.017	− 0.35	−0.64 to − 0.05	< 0.001	− 1.25	− 1.55 to − 0.93
After 3 month	1.72 ± 0.58	1.26 ± 0.59	2.37 ± 0.78	< 0.001	0.46	0.20 to 0.71	< 0.001	−0.65	− 0.89 to − 0.39	<  0.001	− 1.11	−1.36 to − 0.84