Table 3.
Dose volume histogram characteristics
| Characteristic | No radiation pneumonitis (n = 85) | Symptomatic radiation pneumonitis (n = 8) | p value |
|---|---|---|---|
| Contralateral lung V5, % | 0.05 | ||
| Median | 3.1% | 7.4% | |
| Range | 0.0–33.6% | 4.2–53.4% | |
| Ipsilateral lung V30, % | 0.001 | ||
| Median | 3.3% | 9.6% | |
| Range | 0.8–11.6% | 6.5–12.8% | |
| Ipsilateral lung V40, % | 0.003 | ||
| Median | 2.1% | 5.8% | |
| Range | 0.5–8.1% | 3.6–8.8% | |
| Total lung V5, % | 0.001 | ||
| Median | 14.7% | 29.1% | |
| Range | 4.2–46.9% | 18.2–56.9% | |
| Total lung V10, % | 0.001 | ||
| Median | 8.4% | 21.7% | |
| Range | 2.2–34.6% | 10.8–38.4% | |
| MVLS from 12.4 Gy, cm3 | 0.31 | ||
| Median | 3172 cm3 | 2132 cm3 | |
| Range | 969–6807 cm3 | 1439–3592 cm3 | |
| MVLS from 13.5 Gy, cm3 | 0.31 | ||
| Median | 3196 cm3 | 2157 cm3 | |
| Range | 980–6829 cm3 | 1452–3603 cm3 | |
| Total lung V15, % | 0.001 | ||
| Median | 5.4% | 13.2% | |
| Range | 1.2–25.8% | 7.8–18.8% | |
| Total lung V20, % | 0.001 | ||
| Median | 3.4% | 9.1% | |
| Range | 0.8–19.4% | 5.3–12.8% | |
| Total lung V25, % | 0.001 | ||
| Median | 2.4% | 6.7% | |
| Range | 0.6–15.2% | 3.6–9.6% | |
| Total lung V30, % | 0.002 | ||
| Median | 1.8% | 5.1% | |
| Range | 0.5–12.1% | 2.4–7.4% | |
| Total lung V40, % | 0.003 | ||
| Median | 1.1% | 3.3% | |
| Range | 0.3–8.6% | 1.1–4.7% |
Abbreviations: Vdose is the percent of lung receiving greater than the “dose” (in Gy). Symptomatic Radiation Pneumonitis = RTOG G3 + or CTCAE G2 + RP. MVLS = Minimum Volume of Lung Spared
p values from Wilcoxon Rank Sum tests, with all values Bonferroni adjusted. Bolded p values indicate statistical significance