Table 2.
Values of demographic and biochemical variables before and after calcitriol and placebo interventions
| Variable | Baseline | Week 16 | P value | ||||
|---|---|---|---|---|---|---|---|
| Placebo | Calcitriol | Plasebo | Calcitriol | Group | Time | Group * Time | |
| Weight,kg | 83 ± 11.7 | 83 ± 13.1 | 82 ± 12.5 | 83 ± 12.8 | 0.840 | 0.746 | 0.781 |
| BMI, kg/m2 | 29.1 ± 3.9 | 29.1 ± 4.7 | 28.6 ± 4.2 | 28.8 ± 4.5 | 0.595 | 0.754 | 0.812 |
| WC, cm | 101 ± 10.9 | 100 ± 8.9 | 100 ± 11.9 | 100 ± 9.1 | 0.503 | 0.854 | 0.714 |
| HC, cm | 107 ± 7.6 | 106 ± 9.2 | 106 ± 8.6 | 106 ± 9.1 | 0.860 | 0.512 | 0.872 |
| TC, mg/dl | 188 ± 62.0 | 187 ± 46.5 | 187 ± 41.0 | 179 ± 41.8 | 0.441 | 0.827 | 0.783 |
| TG.mg/dl | 180 ± 80.9 | 194 ± 100.1 | 178 ± 92.6 | 177 ± 73.4 | 0.502 | 0.814 | 0.501 |
| HDL-c, mg/dl | 40.9 ± 9.3 | 38 ± 7.9 | 40.8 ± 11.9 | 36 ± 9.8 | 0.001 | 0.262 | 0.990 |
| LDL-c, mg/dl | 96 ± 25.9 | 94 ± 23.4 | 103 ± 22.3 | 99 ± 27.4 | 0.551 | 0.173 | 0.806 |
| FBS, mg/dl | 94 ± 24.0 | 98 ± 38.4 | 94 ± 19.9 | 97 ± 20.0 | 0.881 | 0.908 | 0.813 |
| Insulin, μIU/ml | 10.6 ± 5.6 | 9.2 ± 4.8 | 10.7 ± 5.7 | 9.3 ± 4.2 | 0.737 | 0.646 | 0.761 |
| Homa-IR | 2.1 ± 0.9 | 2.0 ± 0.9 | 2.0 ± 0.8 | 2.0 ± 0.9 | 0.546 | 0.449 | 0.879 |
| Quicki | 0.3 ± 0.03 | 0.3 ± 0.03 | 0.3 ± 0.03 | 0.3 ± 0.03 | 0.433 | 0.343 | 0.672 |
| AST, IU | 27 ± 12.6 | 27 ± 8.7 | 27 ± 14.5 | 23 ± 6.1 | 0.95 | 0.129 | 0.713 |
| ALT, IU | 47 ± 28.5 | 43 ± 16.1 | 35 ± 23.8 | 30 ± 11.4 | 0.209 | 0.000 | 0.650 |
| GGT, IU | 33.5 ± 12.5 | 35.8 ± 21.3 | 30.6 ± 21.1 | 35.9 ± 34 | 0.245 | 0.767 | 0.190 |
| ALK, IU | 198 ± 50.1 | 197 ± 54.9 | 188 ± 50.7 | 169 ± 47.3 | 0.023 | 0.004 | 0.030 |
| HSI Index | 41.5 ± 5.8 | 41.3 ± 5.7 | 38 ± 6.1 | 38.2 ± 6.0 | 0.390 | 0.006 | 0.647 |
| APRI index | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.0 | 0.2 ± 0.0 | 0.154 | 0.242 | 0.983 |
| Hs-CRP, μg/ml | 3.7 ± 3.5 | 4.5 ± 6.0 | 3.4 ± 4.2 | 3.9 ± 5.2 | 0.320 | 0.495 | 0.907 |
| Leptin, ng/ml | 17.5 ± 20 | 14.6 ± 13.9 | 11.3 ± 9.7 | 10.6 ± 12.1 | 0.798 | 0.001 | 0.655 |
| Adiponectin, μg/ml | 20.5 ± 11.3 | 21 ± 14.6 | 18.7 ± 9.7 | 17.5 ± 10.0 | 0.57 | 0.006 | 0.282 |
Values are expressed as the mean ± SD. BMI Body mass index, WC Waist circumference, HC Hip circumference, FBS Fasting blood glucose, Homa-IR Homeostatic Model Assessment for Insulin Resistance, HS index Hepatic steatosis index, APRI AST to Platelet Ratio Index, TC total cholesterol, TG Triglyceride, HDL-c High-density lipoproteins- cholesterol, LDL-c Low density lipoprotein- cholesterol, AST aspartate aminotransferase, ALT Alanine aminotransferase, GGT Gamma-glutamyl transferase, ALK Alkaline phosphatase, Hs-CRP High-sensitivity C-reactive protein