Table 4.
Differential changes of variables following placebo and calcitriol treatments in subjects with FF and Ff genotypes of the VDR FOKI polymorphism
| Variable | FOKI FF genotype(n = 68) | FOKI Ff genotype (n = 58) | p-value | ||||
|---|---|---|---|---|---|---|---|
| placebo | Calcitriol | placebo | Calcitriol | Group | Genotype | Interaction | |
| weight, kg | −0.16 ± 2.4 | 0.24 ± 1.8- | − 1.0 ± 2.3 | 0.5 ± 3.8- | 0.67 | 0.24 | 0.57 |
| BMI, kg/m2 | 0.00 ± 0.75- | −0.21 ± 1.0 | − 0.36 ± 0.8 | 0.2 ± 1.3- | 0.89 | 0.35 | 0.34 |
| WC, cm | −0.8 ± 1.8 | 0.12 ± 2.8 | −0.8 ± 1.9 | −0.3 ± 2.0 | 0.10 | 0.58 | 0.55 |
| HC, cm | 0.16 ± 3.4 | 0.8 ± 3.6- | −0.6 ± 1.4 | − 0.6 ± 3.0 | 0.37 | 0.58 | 0.39 |
| FBS, mg/dl | −2.0 ± 13.5 | 2.0 ± 19.3 | 1.3 ± 9.1 | −4.6 ± 42.8 | 0.82 | 0.71 | 0.27 |
| Insulin | −0.05 ± 6.8 | 0.12 ± 6.4 | 0.2 ± 6.7 | 0.1 ± 4.6 | 0.97 | 0.90 | 0.91 |
| Homa-IR | −0.2 ± 0.7 | 0.1 ± 1.3 | 0.08 ± 0.9 | − 0.2 ± 1.0 | 0.74 | 0.90 | 0.09 |
| TC, mg/dl | −4.5 ± 60.1 | −7.8 ± 33.7 | 1.6 ± 46.1 | −8.8 ± 47.4 | 0.43 | 0.86 | 0.68 |
| TG.mg/dl | −8.1 ± 95.1 | −29.2 ± 99.8 | 5.3 ± 83.2 | 1.0 ± 82.0 | 0.46 | 0.20 | 0.62 |
| HDL -C, mg/dl | −2.2 ± 10.9 | −3.1 ± 9.7 | 1.4 ± 8.8 | −1.2 ± 11.0 | 0.34 | 0.14 | 0.66 |
| LDL-C, mg/dl | 7.5 ± 26.1 | 5.0 ± 21.3 | 7.4 ± 23.7 | 6.4 ± 27.4 | 0.71 | 0.89 | 0.87 |
| AS, IU | 0.08 ± 15.3 | −4.9 ± 7.3 | −1.2 ± 8.5 | −2.4 ± 8.4 | 0.10 | 0.74 | 0.31 |
| ALT, IU | −12.6 ± 22.3 | − 15.3 ± 19.9 | −10.2 ± 17.4 | −11.2 ± 12.2 | 0.58 | 0.34 | 0.80 |
| GGT, IU | 0.18 ± 28.9 | −5.3 ± 13.5 | −5.6 ± 15.6 | 7.6 ± 48.5 | 0.50 | 0.51 | 0.09 |
| ALK, IU | −26.3 ± 74.7 | −23.0 ± 38.1 | 2.2 ± 54.5 | −33.3 ± 42.8 | 0.11 | 0.36 | 0.05 |
| Vitamin D | −0.1 ± 6.4 | 2.1 ± 9.1 | 1.1 ± 6.4 | 0.73 ± 5.9 | 0.13 | 0.39 | 0.86 |
| Hs-CRP,μg/ml | 0.12 ± 3.2 | 0.0 ± 2.9 | −0.38 ± 4.7 | −1.3 ± 6.0 | 0.53 | 0.28 | 0.63 |
| Leptin, ng/ml | −6.3 ± 17.9 | −2.6 ± 12.6 | −6.6 ± 21.1 | −6.2 ± 13.3 | 0.53 | 0.55 | 0.61 |
| Adiponectin, μg/m | −4.5 ± 12.2 | −4.4 ± 14.2 | 0.05 ± 12.8 | −1.8 ± 7.8 | 0.75 | 0.13 | 0.69 |
| HSI | −2.2 ± 3.8 | 3.1 ± 4.5- | − 2.7 ± 4.9 | −2.7 ± 4.1 | 0.56 | 0.92 | 0.54 |
| APRI | 0.0 ± 0.2 | −0.04 ± 0.1 | 0.0 ± 0.1 | −0.03 ± 0.1 | 0.20 | 0.95 | 0.73 |
Values are expressed as the mean ± SD. BMI Body mass index, WC Waist circumference, HC Hip circumference, FBS Fasting blood glucose, Homa-IR Homeostatic Model Assessment for Insulin Resistance, HS index Hepatic steatosis index, APRI AST to Platelet Ratio Index, TC total cholesterol, TG Triglyceride, HDL-c High-density lipoproteins- cholesterol, LDL-c Low density lipoprotein- cholesterol, AST aspartate aminotransferase, ALT Alanine aminotransferase, GGT Gamma-glutamyl transferase, ALK Alkaline phosphatase, Hs-CRP High-sensitivity C-reactive protein