Figure 1.

Amyloid‐β (Aβ) aggregates in surgically resected brain tissue in a subset of patients with severe TBI. A. An example of patients with a focal left frontal contusion injury following severe TBI causing midline shift, obliteration of the basal cisterns and life‐threatening mass effect to the surrounding brain tissue. Immediate surgical removal of the lesion was mandated, allowing immunohistochemical and biochemical analysis of the removed and injured brain tissue. B–D. Immunohistochemical image from the three TBI patients demonstrating accumulation of diffuse (*) and compact (**) insoluble Aβ aggregates.