Figure 2.

GRIP1 is required for AMPAR dynamics and mushroom spine recovery after lesion

(A) Representative pictures of dendritic stretches from non-denervated and denervated Grip1 T956 > A OTCs.

(B and C) Quantification of spine (B) and mushroom spine density (C) as ratios to DPL0 corresponding to (A); n = 8–9 neurons per condition, 4 experiments.

(D–F) Representative reconstructions of mushroom (D), thin (E), and stubby (F) spines from non-denervated and denervated OTCs at DPL2 and DPL21.

(G) Quantification of surface GluA2 in D and ND OTCs, represented as percentage of total GluA2 per compartment; n = 5 neurons per condition, 2 experiments.

Scale bars: 2 μm (A), 1 μm (D)–(F). Graphs show means ± SEMs. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001. Exact p values in Table S1.

See also Figure S3.