Table 5.
Neuronal cell counts in normal‐appearing gray matter (NAGM) and gray matter lesions (GML).
| Target | Neuronal cell counts | ||||
|---|---|---|---|---|---|
| NAGM | GML | Mann–Whitney U test | |||
| Median | IQR | Median | IQR | P value | |
| C1q | 0.0 | 0.00–2.00 | 4.0 | 0.00–6.00 | 0.0003 |
| C3b | 1.0 | 0.00–9.00 | 3.5 | 2.00–8.75 | 0.18 |
| C1INH | 24.0 | 18.00–28.00 | 16.0 | 12.00–20.00 | 0.0003 |
| CR1 | 39.0 | 28.00–45.00 | 25.0 | 18.50–35.00 | 0.002 |
| FH | 27.0 | 19.00–35.00 | 26.0 | 11.70–30.00 | 0.37 |
| Clusterin | 44.5 | 33.75–63.00 | 42.5 | 33.30–53.50 | 0.51 |
| Ox‐24 | 32.5 | 28.50–36.00 | 21.0 | 19.00–24.75 | <0.0001 |
| MBI‐15 | 24.0 | 13.00–30.00 | 20.0 | 10.00–28.75 | 0.21 |
| MBC‐125 | 41.5 | 27.80–51.00 | 29.0 | 17.00–34.00 | 0.005 |
Mann–Whitney U test was used to compare complement proteins and regulator expression on both non‐neuronal (glial) cells and on neuronal cells of NAGM and GML. Positive cells were counted per tissue array core (0.28 mm2 area) and defined as either non‐neuronal (Table 4) or neuronal (Table 5). Median, interquartile range (IQR) and P values are shown. Significance taken at P < 0.05 and shown in BOLD.