Table 2.

Severity of neuropathological lesions on histological sections and intensity of astrocytosis, inflammation, and viral infection in different brain territories in the three cases

Case	Territories	NP lesions H&E	Astrocytosis IHC	Inflammation IHC	Viral infection ISH
1	Cortical plate	High	Mild	Mild	High
	Subcortical zone	High	High	High	Low
	Intermediary zone	High	High	High	Low
	Ventricular zone	Mild	Mild	Mild	High
	Brainstem/Cerebellum	Mild	Mild	Mild	NA
	Spinal cord	Very low	Low	Very low	NA
2	Cortical plate	High	Mild	Mild	High
	Subcortical zone	High	High	Mild	Low
	Intermediary zone	High	High	High	Low
	Ventricular zone	Mild	Mild	Mild	High
	Brainstem/Cerebellum	Low	Mild	Mild	NA
	Spinal cord	Low	Mild	Low	NA
3	Cortical plate	High	Low	Mild	High
	Subcortical zone	Mild	Mild	Mild	Low
	Intermediary zone	Mild	Mild	Mild	Low
	Ventricular zone	Low	Low	Mild	High
	Brainstem/Cerebellum	Mild	Mild	Mild	NA
	Spinal cord	Low	Mild	Low	NA

NP lesions: Neuropathological lesions; H&E: Hematein and Eosin; IHC: Immunohistochemistry; ISH: In situ Hybridization; NA = not applicable.