Table 5. .
Quality of Available Evidence Using GRADE
| Quality Assessment Criteria |
Effect on Orthodontic Relapse |
Quality |
|||||
| Studies |
Risk of Bias |
Inconsistency |
Indirectness |
Imprecision |
Other Considerations |
||
| Bisphosphonates: pamidronate disodium | |||||||
| 1 | Not serious | Not serious | Seriousa | Seriousb | None | Decrease | ⊕⊕○○LOW |
| Analgesics: aspirin | |||||||
| 1 | Not serious | Not serious | Seriousa | Seriousb | None | Decrease | ⊕⊕○○LOW |
| Antibiotics: chemically modified tetracycline-3 | |||||||
| 1 | Not serious | Not serious | Seriousa | Seriousb | None | Decrease | ⊕⊕○○LOW |
| Antihyperlipidemic agents: atorvastatin | |||||||
| 1 | Not serious | Not serious | Seriousa | Seriousb | None | Decrease | ⊕⊕○○LOW |
| Antihyperlipidemic agents: simvastatin | |||||||
| 3 | Not serious | Seriousc | Seriousa | Seriousb | None | Inconsistent effects | ⊕○○○VERY LOW |
a
Results cannot be directly extrapolated to human clinical settings.
b
The number of animals analyzed were limited.
c
Inconsistent or conflicting effects were noted.