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. 2018 Oct 10;28(6):844–859. doi: 10.1111/bpa.12629

Figure 2.

Figure 2

Phenomena of cortical small vessel pathology in SHRSP demonstrated using intravital 2‐photon microscopy. B shows small vessel wall damage indicated by Dextran accumulations in the small vessel walls (arrows). C demonstrates erythrocyte accumulations within an arteriolar wall (arrows) and D shows Dextran accumulations within the small vessel lumen (arrow). In E (arrow) the luminal formation of non‐occlusive erythrocyte thrombi is demonstrated together with intraluminal Dextran accumulations (arrowhead). Non‐occlusive erythrocyte thrombi then transform to occlusive erythrocyte thrombi (F, arrow) together with luminal Dextran accumulations (arrowhead) or later to totally obstructed vessel segments (F, asterisk). A refers to HA stage 0 (no HA features), B and C refer to HA stage 1A (small vessel wall damage), D indicates HA stage 1B (RBC flow reduction), E refers to stage 2 (non‐occlusive thrombus formation) and F refers to HA stage 3 (occlusive thrombus formation). Data refer to the investigation of 21 male SHRSP aged 17–44 weeks. HA, hypertensive arteriopathy; RBC, red blood cell. A–F: scale bars = 50 μm; age of the animals: D and E—18 weeks (w), C—32w, A—33w, B and F—44w.