Figure 7.

Non‐amyloid HA cascade related CAA development. A demonstrates non‐pathological vessels without any HA phenomena (A, stage 0). Non‐amyloid HA‐related changes are initiated by small vessel wall damage and blood flow reductions indicated by the accumulation of Dextran and erythrocytes in the small vessel wall (B, stage 1A) or Dextran in the small vessel lumen (C, stage 1B). The walls of small vessels with subsequent formation of non‐occlusive (D) or occlusive thrombi (E) accompanied by a significant reduction of RBC flow velocity are prone to accumulate (peri)vascular amyloid deposits. CAA, cerebral amyloid angiopathy; HA, hypertensive arteriopathy; RBC, red blood cell.