Table 2.
Transmissibility of animal prion diseases in animal models of the human species barrier.
| Prion diseases | Positive transmission reported in animal models of the human species barrier | |||
|---|---|---|---|---|
| New World Primates* | Old world Primates* | Human PrP expressing transgenic mice‡ | ||
| Cattle | C‐BSE | Yes (IC and oral route) (12) | Yes (IC, intravenous and oral route) | Yes (10, 36, 54,66, 69, 104) |
| (65, 84, 87) | No (25) | |||
| Atypical H‐BSE | – | still ongoing (IC route) (41) | No (20, 142) | |
| Atypical L‐BSE | – | Yes (IC route) (40, 103) | Yes (20, 69, 75) | |
| No (142) | ||||
| Small Ruminants | Classical Scrapie§ | Yes (IC route) (12) | Yes (IC Route) (41) | Yes (36) |
| Atypical Scrapie | – | Ongoing experiment (IC route) (41) | No (107, 141, 142) | |
| Cervids | CWD§ (North American isolates) | Yes (IC and oral route) (109) | No (IC and oral route) (109) | No (74, 125, 142) |
| Yes (IC and oral route)¶ | ||||
*
Squirrel monkeys or Marmoset.
†
Cynomolgus Macaques –.
‡
Mice were all inoculated by the intracerebral route (IC) –.
§
These prion diseases are associated with multiple prion strains.
¶
Czub et al personal communication: https://www.cdc.gov/prions/cwd/transmission.html.