Table 1.
Summary of cases used for mRNA expression, western blot and mitochondrial activity studies in the frontal cortex area 8 (FC) and in the angular gyrus (AG). PD: Parkinson's disease, 0: Cases 1–34 are middle‐aged individuals with no neurological symptoms and without neuropathological evidence of disease; iPD: incidental PD (cases 35–49, stages 3, 4 of Braak without clinical symptoms of parkinsonism), PD: treated parkinsonism of long duration (cases 50–69, stages 5, 6 of Braak); PDD: PD with dementia (cases 70–73, stage 6 with long‐lasting parkinsonism and late development of dementia); M: male; F: female; Age in years; post‐mortem delay in hours and minutes; RIN: values of RNA integrity number; WB: western blot; MA: mitochondrial activity complexes.
| No case | PD | Gender | Age | PM delay | RIN FC | RIN AG | WB FC | WB AG | MA FC | MA AG |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 0 | MALE | 64 | 8 h 30 m | 7.7 | 7.7 | X | X | – | – |
| 2 | 0 | MALE | 56 | 5 h | 7.8 | 6.8 | X | X | X | – |
| 3 | 0 | MALE | 67 | 5 h | 7.4 | 6.7 | X | X | – | – |
| 4 | 0 | MALE | 62 | 3 h | 8 | 6.8 | X | X | – | – |
| 5 | 0 | MALE | 52 | 4 h 40 m | 8.1 | 6.7 | X | X | – | – |
| 6 | 0 | MALE | 30 | 4 h 10 m | 8.4 | – | X | – | – | – |
| 7 | 0 | MALE | 53 | 3 h | 8.8 | 6.6 | X | X | X | – |
| 8 | 0 | FEMALE | 49 | 7 h | 8.2 | – | X | – | – | – |
| 9 | 0 | FEMALE | 75 | 3 h | 7.7 | 8.7 | X | X | – | – |
| 10 | 0 | FEMALE | 46 | 9 h 35 m | 6.8 | 6.8 | X | X | – | – |
| 11 | 0 | FEMALE | 86 | 4 h 15 m | 8.1 | – | X | – | – | – |
| 12 | 0 | FEMALE | 79 | 3 h 35 m | 7.7 | – | X | – | – | – |
| 13 | 0 | FEMALE | 79 | 6 h 25 m | 7.8 | – | X | – | – | – |
| 14 | 0 | FEMALE | 77 | 3 h 15 m | 7 | – | X | – | – | – |
| 15 | 0 | FEMALE | 76 | 5 h 45 m | 8.3 | – | – | – | – | – |
| 16 | 0 | FEMALE | 71 | 8 h 30 m | 7.4 | – | – | – | – | – |
| 17 | 0 | MALE | 56 | 5 h | 6.9 | – | – | X | – | X |
| 18 | 0 | FEMALE | 78 | 12 h | 6.5 | – | – | X | – | X |
| 19 | 0 | MALE | 71 | 3 h | – | – | – | X | – | X |
| 20 | 0 | MALE | 103 | 3 h | – | – | – | X | – | X |
| 21 | 0 | MALE | 59 | 4 h 15 m | – | – | – | – | – | X |
| 22 | 0 | MALE | 61 | 4 h 30 m | – | – | – | – | – | X |
| 23 | 0 | MALE | 70 | 13 h | – | – | – | – | X | – |
| 24 | 0 | MALE | 39 | 9 h 15 m | – | – | – | – | X | – |
| 25 | 0 | FEMALE | 64 | 2 h 15 m | – | – | – | – | X | – |
| 26 | 0 | MALE | 52 | 4 h 40 m | – | – | – | – | X | – |
| 27 | 0 | MALE | 79 | 7 h 45 m | 7.1 | – | – | – | – | – |
| 28 | 0 | MALE | 52 | 3 h 30 m | 8 | – | – | – | – | – |
| 29 | 0 | MALE | 51 | 4 h | 6.5 | – | – | – | – | – |
| 30 | 0 | MALE | 75 | 9 h | 6.6 | – | – | – | – | – |
| 31 | 0 | MALE | 58 | 4 h | 7.7 | – | – | – | – | – |
| 32 | 0 | MALE | 82 | 11 h | 6.6 | – | – | – | – | – |
| 33 | 0 | MALE | 73 | 7 h | 7.2 | – | – | – | – | – |
| 34 | 0 | MALE | 73 | 5 h 30 m | 7 | – | – | – | – | – |
| 35 | iPD | MALE | 57 | 11 h | 8.7 | 8.3 | X | X | – | – |
| 36 | iPD | FEMALE | 54 | 11 h 10 m | 8.2 | – | X | X | – | – |
| 37 | iPD | FEMALE | 70 | 10 h 50 m | – | 8.7 | – | X | – | – |
| 38 | iPD | MALE | 66 | 5 h | 7.3 | 7.3 | X | X | – | – |
| 39 | iPD | MALE | 72 | 5 h | 7.7 | – | – | – | – | – |
| 40 | iPD | MALE | 57 | 19 h | 7.6 | 7 | X | X | – | – |
| 41 | iPD | MALE | 76 | 4 h 30 m | 7.7 | 7.9 | X | X | – | – |
| 42 | iPD | MALE | 68 | 4 h 45 m | 7.3 | 8.5 | X | X | – | – |
| 43 | iPD | MALE | 79 | 9 h 15 m | 7.2 | – | X | X | – | – |
| 44 | iPD | MALE | 69 | 5 h 55 m | 6.4 | 7.6 | X | X | – | – |
| 45 | iPD | MALE | 68 | 9 h 20 m | 6.9 | – | – | – | – | – |
| 46 | iPD | MALE | 77 | 12 h | 6.9 | – | – | – | – | – |
| 47 | iPD | FEMALE | 84 | 4 h 30 m | 7.8 | – | – | – | – | – |
| 48 | iPD | MALE | 69 | 15 h 05 m | 8.1 | – | – | X | – | – |
| 49 | iPD | MALE | 78 | 10 h 45 m | 7.3 | – | – | – | – | – |
| 50 | PD | FEMALE | 70 | 4 h 30 m | 8.5 | – | X | – | X | – |
| 51 | PD | FEMALE | 77 | 3 h 30 m | 6.8 | – | X | – | – | – |
| 52 | PD | FEMALE | 81 | 6 h 30 m | 8.3 | – | X | – | – | – |
| 53 | PD | FEMALE | 69 | 4 h 30 m | 8 | – | X | – | – | – |
| 54 | PD | FEMALE | 79 | 3 h 30 m | 8 | – | X | – | X | – |
| 55 | PD | MALE | 78 | 13 h 30 m | 6.7 | – | – | – | – | – |
| 56 | PD | MALE | 83 | 14 h | 7.7 | – | – | – | – | – |
| 57 | PD | FEMALE | 77 | 7 h 30 m | 7.1 | – | – | – | X | – |
| 58 | PD | FEMALE | 84 | 4 h | 7.3 | 6.9 | – | – | X | X |
| 59 | PD | MALE | 76 | 12 h | 6.5 | – | – | – | X | – |
| 60 | PD | MALE | 78 | 13 h 30 m | 7.7 | – | – | – | X | – |
| 61 | PD | MALE | 83 | 14 h | 7 | – | – | – | X | – |
| 62 | PD | MALE | 76 | 21 h 45 m | 7.2 | 6.8 | – | – | X | X |
| 63 | PD | MALE | 79 | 4 h 30 m | 6.8 | 7.5 | – | – | X | X |
| 64 | PD | MALE | 77 | 7 h 30 m | 6.7 | 7 | – | – | X | X |
| 65 | PD | FEMALE | 78 | 4 h 30 m | – | 6.6 | – | X | – | X |
| 66 | PD | FEMALE | 79 | 1 h 30 m | – | 7.2 | – | X | – | X |
| 67 | PD | MALE | 76 | 4 h | – | 6.6 | – | X | – | X |
| 68 | PD | MALE | 84 | 4 h | – | 7.7 | – | X | – | X |
| 69 | PD | MALE | 87 | 7 h 30 m | – | 7.5 | – | X | – | X |
| 70 | PDD | MALE | 80 | 7 h 30 m | 7.2 | 6.6 | X | X | X | X |
| 71 | PDD | MALE | 82 | 16 h 30 m | 7.3 | 6.7 | X | X | X | X |
| 72 | PDD | MALE | 76 | 9 h 40 m | 6.8 | 6.4 | X | X | X | X |
| 73 | PDD | MALE | 84 | 16 h 30 m | 7.1 | 7.4 | X | X | X | X |