Table 4.

Summary of mRNA expression levels of genes encoding subunits of the mitochondrial complexes and energy metabolism‐related enzymes in the angular gyrus in MA, iPD, PD and PDD. Up‐regulated gene expression occurs in PD 3–4 when compared with MA. However, important decay in gene expression is observed in PD 5–6 and PDD when compared with PD 3–4. Student's T‐test *P < 0.05, **P < 0.01, ***P < 0.001. ^†No Gaussian distribution (Mann–Whitney test *P < 0.05, **P < 0.01, ***P < 0.001.

		Angular gyrus
		MA vs. PD 3–4	MA vs. PD 5–6	PD 3–4 vs. PD 5–6	MA vs. PDD	PD 3–4 vs. PDD	PD 5–6 vs. PDD
Mitochondrial elements
Complex I	NDUFA2	–	–	–	–	↓*	–
	NDUFA7	↑**	–	↓***	–	↓**	–
	NDUFA10	↑*	↑*	–	–	↓*	–
	NDUFB3	–	–	–	–	–	–
	NDUFB7	–	–	–	–	–	–
	NDUFB10	↑*	–	↓**	–	↓**	–
	NDUFS7	↑*	–	↓**	–	↓**	–
	NDUFS8	–	–	↓*	–	–	–
Complex II	SDHB	–	–	–	–	↓*	–
Complex III	UQCRB	↑*	–	–	–	–	–
	UQCR11	↑*	–	–	–	↓*	–
Complex IV	COX7A2L	↑*	–	↓**	–	↓**	↓**
	COX7C	–	–	–	–	–	–
Complex V	ATP5D	↑*	–	–	–	–	–
	ATP5G2	↑*	–	–	–	↓*	–
	ATP5H	–	–	–	–	–	–
	ATP5L	–	–	–	–	–	–
	ATP5O	–	–	–	–	↓*	–
Energy metabolism‐related molecules
	ATP2B3	–	–	–	–	–	–
	ATP2B4	–	–	–	↓*	↓*	↓***
	ATP4A	–	–	–	–	–	–
	ATP6V0A1	–	–	–	–	–	–
	ATP6V0B	↑**	–	↓**	–	↓*	–
	ATP6V1H	↑***	–	↓***	–	↓***	↓**
	FAM82A2	–	–	–	↓*	–	↓**
	LHPP	–	–	–	↓*	–	↓**
	SLC6A6	–	–	–	–	↓*	–
	SLC25A31	–	–	–	–	–	–
	TOMM40	–	–	–	–	–	–
	ZNF642	–	–	–	–	↓**	–