Table 1.
Examination summary for Caribbean vervets and Beagle canines.
| Animal | Age (years) | Gender | Brain region examined | 1E4E11 (pSer8Aβ) | 7H3D6 (npAβ) | 82E1 (Aβ1‐x) |
|---|---|---|---|---|---|---|
| Caribbean vervets | ||||||
| Vervet 1 | 7.4 | Female | F | – | – | – |
| T/HC | – | – | – | |||
| Vervet 2 | 11.1 | Female | F | ++ | + | ++ |
| T/HC | – | – | – | |||
| Vervet 3 | 12.2 | Female | F | – | – | – |
| T/HC | – | – | – | |||
| Vervet 4 | 12.4 | Male | F | + | + | + |
| T/HC | – | – | – | |||
| Vervet 5 | 12.8 | Male | F | – | – | + |
| T/HC | – | – | – | |||
| Vervet 6 | 12.9 | Male | F | + | + | + |
| T/HC | + | + | ++ | |||
| Vervet 7 | >15 | Female | F | + | + | +++ |
| T/HC | – | – | + | |||
| Vervet 8 | >15 | Male | F | ++ | – | +++ |
| T/HC | + | + | ++ | |||
| Vervet 9 | 16.4 | Female | F | ++ | – | +++ |
| T/HC | ++ | + | +++ | |||
| Vervet 10 | 16.9 | Female | F | + | + | ++ |
| T/HC | + | + | + | |||
| Vervet 11 * | 19 | Female | F | – | – | – |
| T/HC | – | – | – | |||
| Vervet 12 | 24.5 | Female | F | ++ | + | +++ |
| T/HC | ++ | + | ++ | |||
| Vervet 13 | 27.7 | Female | F | +++ | ++ | +++ |
| T/HC | – | + | ++ | |||
| Vervet 14 | 30.0 | Male | F | + | + | +++ |
| T/HC | + | + | ++ | |||
| Vervet 15 | 32.0 | Female | F | + | + | + |
| T/HC | ++ | + | ++ | |||
| Beagle canines | ||||||
| Canine‐1 | 10 | NA | PF | + | + | + |
| Canine‐2 | 12 | NA | PF | ++ | + | ++ |
| Canine‐3 | 14 | NA | PF | +++ | ++ | + |
Semi‐quantitative scoring of general Asp‐1 (82E1)‐ and phosphorylation‐state specific (7H3D6 and 1E4E11)‐ antibody reactivity against immunoreactive Asp1 Aβ plaques (82E1) and non‐phospho and pSer8Aβ‐positive plaques in the brains of 15 Caribbean vervets and 3 canines. Degree of plaques and blood vessel immunoreactivity: ‐, no positive plaques and blood vessels; + low number of positive plaques and blood vessels; ++, moderate number of positive plaques and blood vessels; +++ numerous positive plaques and blood vessels. NA; not available.
*General Aβ plaque immunoreactivity was observed in pre‐frontal cortex in another study, suggesting this animal was in very early stages of plaque deposition.