Table 1.
TargetScan7.2 predicted target sites of mimic candidates with PRNP 3′UTR. Units in brackets indicate the number of predicted interaction sites when using poorly conserved miRNA family criteria. CLIP detected miRNA‐PRNP interactions and their respective target sites in PRNP transcript (Ensembl ID:ENST00000379440.8) are also illustrated. Underscores indicate binding to the CDS and bold lettering indicates a closely related miRNA family member.
| Hits | Predicted | CLIP Site | Reference |
|---|---|---|---|
| 20b‐5p | Yes (1) | 2279‐2307 | Boudreau RL et al 9 |
| 148a‐3p | Yes (2) | 2466‐2488 | Balakrishnan I et al 3 |
| 148b‐3p | Yes (2) | 1186‐1193, 2466‐2488 | Boudreau RL et al 9 |
| 152‐3p | Yes (2) | 2464‐2488 | Balakrishnan I et al 3 |
| 188‐3p | Yes (1) | No | N/A |
| 192‐3p | No | No | N/A |
| 338‐5p | Yes (2) | 2234‐2253 | Balakrishnan I et al 3 |
| 342‐5p | No | No | N/A |
| 371a‐3p | 371b‐3p (1) | No | N/A |
| 519d‐3p | Yes (1) | 2289‐2307 | Balakrishnan I et al 3 |
| 4686 | Yes (1) | No | N/A |
| 5588‐3p | Yes (1) | No | N/A |
| 124‐3p | No | No | N/A |
| 193a‐3p | Yes (1) | 1276‐1284 | Balakrishnan I et al 3 |
| 193b‐3p | Yes (1) | No | N/A |
| 299‐5p | No | 581‐609 | Balakrishnan I et al 3 |
| 376b‐3p | 376c‐3p (1) | 2302‐2321 | Boudreau RL et al 9 |
| 519b‐3p | Yes (1) | No | N/A |
| 4802‐5p | No | No | N/A |