Table 1.

Patient characteristics.Characteristics of seven patients harboring cerebral amyloidoma. Progression free survival (PFS) was defined as the time from first diagnosis until clinical and/or radiological amyloidoma progression and/or death from any cause (IHC, immunohistochemistry; CISH, chromogenic in situ‐hybridization; IgH, IgH Gene Clonality Assay; AL‐λ, lambda light chain amyloidosis; AL κ, kappa light chain amyloidosis; CT, computer tomography; MRI, magnetic resonance imaging; *pseudo‐clonality could not be excluded, probably because of low cellularity of the sample).

Case	Sex	Age	Presenting symptoms	Location	Neuroimaging	Surgery	Postoperative Treatment	PFS (months)	Medical condition at last follow‐up	IHC	CISH	IgH
1	Male	50 years	Confusion, headache, vomiting and visual deficits of the lower right quadrant, dyslexia	Left occipital	MRI: 75 x 50 mm lesion with minor contrast enhancement	Biopsy	Steroids	17	Stable. Minor residual visual impairment.	Inconclusive	AL‐κ	Clonality
2	Male	35 years	Intermittent headache, right leg paresis	Left pre‐central	CT and MRI: subcortical 20 x 15 mm lesion with contrast enhancement and minor perifocal edema	Biopsy	Anticonvulsants	180	Stable. Epileptiform activity on EEG.	Inconclusive	AL‐λ	Not evaluable
3	Female	49 years	Seizures	Right frontal	MRI: 58 x 49 x 35 mm lesion with inhomogeneous contrast enhancement	Gross total resection	Anticonvulsants	11	Stable. Epileptiform activity on EEG.	Inconclusive	AL‐λ	Clonality
4	Female	53 years	Seizures, left homonymous hemianopsia, hemiparesis and numbness of left hand and foot	Right parieto‐occipital	PET‐MRI: 66 x 38 x 31 mm right parieto‐occipital lesion with inhomogeneous contrast enhancement. Multiple additional smaller lesions.	Partial resection	Steroids	24	Stable. Minor residual left‐sided hemiparesis, dysphagia and visual impairment.	Inconclusive	AL‐λ	Clonality
5	Female	52 years	Seizures	Right temporal	CT and MRI: 35 x 22 x 25 mm lesion with contrast enhancement. Focal calcifications and minor perifocal edema	Partial resection	Steroids, anticonvulsants	71	Stable. No further seizures.	AL‐λ	AL‐λ	Clonality*
6	Female	49 years	Depression, frontal lobe disorder, seizures, numbness of the right half of the body	Left frontal	CT and MRI: 50 x 50 x 35 mm lesion with inhomogeneous contrast enhancement, midline shift, perifocal edema	Biopsy	Steroids, radiation (20Gy)	21	Stable. Minor residual numbness and spasticity.	AL‐λ	AL‐λ	Clonality
7	Male	52 years	Vertigo	Right thalamus	MRI: 15 x 13 x 12 mm thalamic lesion with midline shift	Partial resection	None	4	Stable. No symptoms.	Inconclusive	AL‐λ	Clonality