Table 1.

Summarizes all parameters that were assessed and the changes that occurred in the experimental groups compared to the control are indicated. GFP expression was significantly enhanced in all 3 experimental groups. Staining for MBP (myelin basic protein) was decreased in all 3 experimental groups. The number of NG2 cells was significantly enhanced only in the 5 weeks of Cuprizone plus 1 week of remyelination group, whereas the number was not significantly altered in the other groups. The number of CC1 positive cells was significantly decreased in the 5 weeks of Cuprizone feeding group only. The number of Nav1.6 positive nodes was increased in all experimental groups, although the difference was only significant in the 5 weeks of Cuprizone plus 5 weeks of remyelination. By contrast, the number of axons displaying vesicles was significantly enhanced in all three Cuprizone‐treated groups, while it was highest in the 5 weeks of Cuprizone group.

Group	GFP expression	MBP staining	Number of NG2 cells	Number of CC1 cells	Number of Nav1.6‐positive nodes of Ranvier	Number of axons containing vesicles
5 weeks of cuprizone feeding	↑	↓	~	↓	~	↑↑
5 weeks of cuprizone feeding + 1 week of remyelination	↑	↓	↑	~	~	↑
5 weeks of cuprizone feeding + 5 week of remyelination	↑	↓	~	~	↑	↑