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. 2019 Apr 10;29(6):741–770. doi: 10.1111/bpa.12718

Figure 1.

Figure 1

Preformed α‐synuclein fibril injections in the mouse OB/AON accelerate mortality in older mice without significant changes in body weight. Sixty‐four mice were infused in the right olfactory bulb/anterior olfactory nucleus with either preformed α‐synuclein fibrils (5 μg/1 μL) or an equivalent volume of PBS (1 μL) at the indicated ages. Logrank survival analyses were performed for all animals at 6 months post‐infusion (A) and for the older males at 6 months (B) or 10.5 months (C) post‐infusion. The two‐tailed P‐values of the logrank survival analyses are shown. (D) The body weights of the older males at surgery (11 months old), 6 months post‐surgery (17 months old), and 10.5 months post‐surgery (21.5 months old) are displayed as scatter plots with mean and SEM bars. In panel D, crosses are placed next to mice that died before the planned time of assay. (E‐F) Weight gained in both raw numbers (E) and percentage weight gain (F) 6 months after surgery in all experimental groups. Note the broken Y axis in panels A and D. For panels D‐F, two‐way ANOVAs were followed by the Bonferroni post hoc correction for multiple comparisons. In panels E‐F, +++ P ≤ 0.001 vs. males that were infused at 3 months of age and perfused at 9 months of age (3–9 month males).