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. 2019 Mar 24;29(4):502–512. doi: 10.1111/bpa.12688

Figure 2.

Figure 2

Expression of mRNA of early growth response 1 (EGR1) and acetylcholinesterase (AChE) in the frontal cortex of triple‐transgenic AD (3xTg‐AD) and wild type (WT) mice. A. EGR1‐mRNA and (C) AChE‐mRNA both significantly decreased in the entire group of 3xTg‐AD mice compared with WT mice (Student’s t‐test, P = 0.031 and P < 0.001). In addition, B. EGR1‐mRNA significantly decreased in the 7–8‐months group (Student’s t‐test, P = 0.025), while (D) AChE‐mRNA significantly decreased in the 7–8‐months group (Student’s t‐test, P = 0.0103) and the 11–12‐months group (Student’s t‐test, P = 0.041) compared with their respective month‐of‐age WT group. The WT mice showed stable (B) EGR1‐mRNA and (D) AChE‐mRNA expression among the different months of ages (ANOVA, F(2,51) = 0.0824, P = 0.921 and F(2,50) = 0.125, P = 0.883). The 3xTg‐AD mice, on the other hand, showed significant changes in (B) EGR1‐mRNA levels among ages (ANOVA, F(2,52) = 4.355, P = 0.018), especially in the 7–8‐months group compared with the 3–4‐months group (Bonferroni test, P = 0.019), while (D) AChE‐mRNA expression was stable among different months of age (ANOVA, F(2,52) = 0.435, P = 0.65). The normalized data (square root transformation) are represented as mean (± standard deviation). (*) compared with corresponding WT, (#) compared with the 3–4‐months group. *P < 0.05, ***P < 0.001, # P < 0.05.