Table 4.

Odds ratios [95% confidence intervals] for cancer risk behaviours at age 24 years (imputed sample)

Harmful drinking	Unadjusted analysis	p-value	Partially adjusted analysisa	p-value	Fully adjusted analysisb	p-value
	Odds ratios [95% CIs]		Odds ratios [95% CIs]		Odds ratios [95% CIs]
Q1 (referent category)	1	p ≤ 0.001	1	p ≤ 0.001	1	p ≤ 0.001
Q2	1.20 [0.92,1.55]		1.27 [0.98,1.65]		1.29 [0.99,1.68]
Q3	1.54 [1.21,1.96]		1.69 [1.32,2.17]		1.71 [1.33,2.19]
Q4	1.71 [1.33,2.18]		2.03 [1.57,2.62]		2.04 [1.57,2.65]
Linear association	1.04 [1.03,1.06]	p ≤ 0.001	1.06 [1.04,1.08]	p ≤ 0.001	1.06 [1.04,1.08]	p ≤ 0.001
Daily smoking
Q1 (referent category)	1	p ≤ 0.001	1	p ≤ 0.001	1	p ≤ 0.001
Q2	1.69 [1.14,2.51]		1.61 [1.08,2.40]		1.57 [1.05,2.3]
Q3	2.73 [1.86,3.99]		2.57 [1.75,3.79]		2.50[1.69,3.70]
Q4	5.89 [4.04,8.58]		5.71 [3.90,8.38]		5.37[3.64,7.93]
Linear association	1.18 [1.15,1.22]	p ≤ 0.001	1.18 [1.15,1.22]	p ≤ 0.001	1.18[1.15,1.21]	p ≤ 0.001
Nicotine dependence
Q1 (referent category)	1	p ≤ 0.001	1	p ≤ 0.001	1	p ≤ 0.001
Q2	1.50 [0.87,2.58]		1.42 [0.82,2.46]		1.37 [0.79,2.38]
Q3	2.54 [1.57,4.12]		2.36 [1.46,3.84]		2.26 [1.39,3.69]
Q4	5.93 [3.75,9.36]		5.61 [3.53,8.93]		5.10 [3.19,8.17]
Linear association	1.19 [1.15, 1.23]	p ≤ 0.001	1.18 1.14, 1.23]	p ≤ 0.001	1.18 [1.13, 1.22]	p ≤ 0.001
Obesityc
Q1 (referent category)	1	p ≤ 0.001	1	p ≤ 0.001	1	p ≤ 0.001
Q2	1.54 [1.05,2.28]		1.48 [1.00,2.19]		1.52 [0.98,2.34]
Q3	2.70 [1.89,3.84]		2.53 1.77,3.61]		2.41 [1.62,3.58]
Q4	5.74 [4.12,8.00]		5.26 [3.76,7.37]		4.84 [3.33,7.03]
Linear association	1.18 [1.15, 1.21]	p ≤ 0.001	1.17 [1.14, 1.20]	p ≤ 0.001	1.16 [1.13, 1.19]	p ≤ 0.001
Waist circumferencec
Q1 (referent category)	1	p ≤ 0.001	1	p ≤ 0.001	1	p ≤ 0.001
Q2	1.34 [1.08,1.68]		1.25 1.00,1.57]		1.24 [0.97,1.59]
Q3	1.77 [1.43,2.19]		1.59 [1.28,1.98]		1.53 [1.21,1.94]
Q4	3.17 [2.55,3.93]		2.66 [2.13,3.32]		2.48 [1.94,3.16]
Linear association	1.12 [1.10,1.14]	p ≤ 0.001	1.10 [1.08, 1.12]	p ≤ 0.001	1.09 [1.07, 1.12]	p ≤ 0.001
Waist-to-hip ratioc
Q1 (referent category)	1	p ≤ 0.001	1	p ≤ 0.001	1	p ≤ 0.001
Q2	1.47 1.04,2.10]		1.27 [0.88,1.83]		1.29 [0.87,1.91]
Q3	1.72 [1.23,2.40]		1.37 [0.97,1.95]		1.32 [0.90,1.94]
Q4	2.87 [2.09,3.93]		1.98 [1.42,2.78]		1.88 [1.30,2.71]
Linear association	1.10 [1.07, 1.13]	p ≤ 0.001	1.07 [1.04, 1.09]	p ≤ 0.001	1.06 [1.03, 1.09]	p ≤ 0.001

^a Adjusted for sex, IQ, parental socio-economic status (maternal education, parental social class, household equivalised income and housing tenure) and adverse childhood experiences (ACEs)

^b Additionally adjusted for maternal cannabis use, maternal harmful alcohol use and maternal smoking and child depressive symptoms (SMFQ), child antisocial behaviour and child total difficulties score (SDQ)

^c These analyses were additionally, adjusted for birthweight and gestational age in the partially adjusted analysis and maternal obesity, maternal physical inactivity and maternal unhealthy diet in the fully adjusted analysis