Table 2.
Univariable and multivariable Cox regression analysis in GBM
| Characteristics | Subset | Univariate analysis Hazard ratio (95%CI) |
P value | Multivariate analysis Hazard ratio (95%CI) |
P value |
|---|---|---|---|---|---|
| Age | ≤48/> 48 | 1.378 (0.451–4.214) | 0.751 | 1.794 (0.243–4.241) | 0.981 |
| Gender | Male/Female | 1.556 (0.643–3.749) | 0.327 | 3.165 (0.981–10.210) | 0.885 |
| Chr7 gain/Chr10 loss | Yes/No | 0.318 (0.126–0.804) | 0.015* | 0.908 (0.246–3.358) | 0.054 |
| 1p/19q status | Code/Noncoded | 9.036 (7.841–37.803) | 0.000* | 4.355 (1.121–16.443) | 0.002* |
| IDH status | Mutation/Wild | 0.630 (2.701–3.242) | 0.003* | 0.170 (0.042–0.691) | 0.013* |
| MGMT promoter status | Mutation/Wild | 7.151 (3.606–81.581) | 0.011* | 5.706 (1.986–34.619) | 0.064 |
| OXCT1-AS1 | High/Low | 0.701 (0.191–0.541) | 0.000* | 0.468 (0.094–0.361) | 0.014* |
In both univariable and multivariable Cox regression analyses, all characteristics were evaluated as continuous variables. P < 0.05 was considered statistically significant in all analyses.