Table 1.
A literature review of the comparative studies between p53 IHC and TP 53 mutations
| Author | Year | Histology (WHO grade) | No. | Method | Exon | Concordance rate (%) | Immunohistochemistry | False positive (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IHC(+)/Mut(+) | IHC(+)/Mut(−) | IHC(−)/Mut(+) | IHC(−)/Mut(−) | ||||||||
| Louis | 1993 | Astrocytic gliomas (II–IV) | 34 | SSCP | 5–8 | 59 | 8 | 10 | 4 | 12 | 29.4 |
| Newcomb | 1993 | Glioblastoma (IV) | 37 | SSCP | 2–11 | 81 | 17 | 7 | 0 | 13 | 18.9 |
| Koga | 1994 | Glioma (II–IV) | 19 | SSCP + Seq | 4–8 | 74 | 5 | 3 | 2 | 9 | 15.8 |
| Lang | 1994 | Astrocytic gliomas (I–III) | 31 | SSCP + Seq | 2–11 | 55 | 6 | 14 | 0 | 11 | 45.2 |
| Schiffer | 1995 | Glioma (I–IV) of childhood | 30 | SSCP + Seq | 5–8 | 73 | 3 | 8 | 0 | 19 | 26.7 |
| Hagel | 1996 | Oligodendrocytic gliomas (II–IV) | 122 | SSCP | 5–9 | 82 | 7 | 15 | 7 | 93 | 12.3 |
| Kyritsis | 1996 | Glioma (II–IV) | 61 | Seq | 5–8 | 82 | 17 | 7 | 4 | 33 | 11.5 |
| Watanabe | 1997 | Astrocytic gliomas (II–IV) | 144 | SSCP + Seq | 4–8 | 74 | nd | 26 | 9 | nd | 18.1 |
| Gillet | 2014 | Glioma (II) | 59 | Ion Torrent + Seq | 1–11 | 78 | 24 | 6 | 7 | 22 | 10.2 |
| This study | 2014 | Glioma (II–IV) | 157 | Seq | 4–10 | 89 | 52 | 3 | 14 | 88 | 2.5 |
Abbreviations: IHC = immunohistochemistry; Seq = DNA sequencing; SSCP = single‐strand conformation polymorphism; WHO = World Health Organization.